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HRID1478646

反应详情

EQUATION

反应方程式

HRID 1478646 的结构方程式

REACTANTS

反应物

3
结构：[N-]=[N+]=Nc1c(F)cccc1F
HCID11579166

Benzene, 2-azido-1,3-difluoro-

C6H3F2N3

结构：CCC[CH2][Sn]([CH2]CCC)([CH2]CCC)[O]C(C)=O
HCID16682741

Tributyltin acetate

C14H30O2Sn

结构：C#CCNC(=O)[C@H](Cc1cscn1)NC(=O)[C@H]1O[C@@H]1C(=O)OCC
HCID71817782

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](Cc1cscn1)C(=O)NCc1cn(-c2c(F)cccc2F)nn1
HCID131736517

未命名化合物

收率 31.6%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O=S(=O)([O-])[O-].[Cu+2]
催化剂HCID24462

Copper sulfate

CuO4S

结构：CC(C)(C)O.CCO.O
溶剂HCID86659795

未命名化合物

PROCEDURE

实验过程

The general click procedure was used substituting the following quantities using: 37 (48 mg, 0.14 mmol); 2-azido-1,3-difluorobenzene (24 mg, 0.15 mmol); CuSO4 (3.5 mg, 0.02 mmol); NaAsc (18 mg, 0.09 mmol); TBTA (12 mg, 0.01 mmol); in t-BuOH/EtOH/H2O (1:1:0.5); afforded 46 as a white solid (20 mg, 31.6%). 1H NMR (DMSO-d6, 400 MHz): δ 8.74-8.73 (d, 1H, J=1.79 Hz); 7.74-7.72 (m, 2H); 7.55-7.45 (m, 1H); 7.34-7.32 (m, 1H); 7.17-7.13 (t, 2H); 7.04-7.03 (d, 1H, J=1.72 Hz); 4.82-4.80 (q, 1H); 4.57-4.56 (d, 2H, J=5.97 Hz); 4.29-4.24 (m, 2H); 3.71-3.70 (d, 1H, J=1.78 Hz); 3.55-3.54 (d, 1H, J=1.78 Hz); 3.35-3.18 (m, 2H); 1.33-1.30 (t, 3H). 13C NMR (CDCl3, 100 MHz): 170.16, 166.65, 166.30, 158.01, 155.46, 153.29, 152.24, 144.36, 131.48, 129.14, 125.10, 116.01, 112.64, 62.24, 53.81, 52.74, 52.62, 34.74, 32.91, 13.99.