Tetrahydro-2-furoic acid, (-)- → (2S)-N-methoxy-N-methyloxolane-2-carboxamide

HRID 1478770Notes

Reaction equation

HRID 1478770 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[C:6]([OH:8])=O.[CH3:9][O:10][N:11](C)[C:12]([C@@H]1C[C@H]1C)=O>>[CH3:9][O:10][N:11]([CH3:12])[C:6]([C@@H:2]1[CH2:3][CH2:4][CH2:5][O:1]1)=[O:8]

Participants

3

Reactant 2

HCID 446666Tetrahydro-2-furoic acid, (-)-HCID 90253492HCID 90253492, compound

Product 1

HCID 6712977(2S)-N-methoxy-N-methyloxolane-2-carboxamide

Procedure

(2S)-Tetrahydrofuran-2-carboxylic acid was converted to the product using the method described for the synthesis of (1R,2R)—N-methoxy-N,2-dimethylcyclopropanecarboxamide (C79) in Example 20. The resulting product was used in the next step without further purification. Yield: 24.6 g, ≦0.153 mol, ≦90%.

Workup

  1. customThe resulting product was used in the next step without further purification

Sources & evidence

ORD record
ord-e950af13e09a4c12ad116644d2b64b03
Source dataset
uspto-grants-2016_08
Patent number
US09403846B2

Reaction notes

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