HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydro-2-furoic acid, (-)- → (2S)-N-methoxy-N-methyloxolane-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydro-2-furoic acid, (-)- | HCID 446666 | — |
| Reactant | HCID 90253492 | HCID 90253492 | — |
| Product | (2S)-N-methoxy-N-methyloxolane-2-carboxamide | HCID 6712977 | — |
Reaction Steps
(2S)-Tetrahydrofuran-2-carboxylic acid was converted to the product using the method described for the synthesis of (1R,2R)—N-methoxy-N,2-dimethylcyclopropanecarboxamide (C79) in Example 20. The resulting product was used in the next step without further purification. Yield: 24.6 g, ≦0.153 mol, ≦90%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09403846B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-e950af13e09a4c12ad116644d2b64b03 |
| Source note | uspto-grants-2016_08 |