HCID 102287610, compound → HCID 118513297, compound

HRID 1478812Notes

Reaction equation

HRID 1478812 reaction equation
[CH2:1]([C:4]1[CH:9]=[C:8]([O:10][C:11]([F:14])([F:13])[F:12])[CH:7]=[CH:6][C:5]=1[NH:15][C:16](=[O:19])[CH:17]=[CH2:18])C=C>C(Cl)Cl>[F:14][C:11]([F:12])([F:13])[O:10][C:8]1[CH:7]=[CH:6][C:5]2[NH:15][C:16](=[O:19])[CH:17]=[CH:18][CH2:1][C:4]=2[CH:9]=1

Participants

3

Reactant 1

HCID 102287610HCID 102287610, compound

Product 1

HCID 118513297HCID 118513297, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of N-(2-allyl-4-(trifluoromethoxy)phenyl)acrylamide (15 g, 55.3 mmol) in DCM (800 ml) was added Zhan catalyst I (2.0 g, 2.77 mmol) and the mixture was stirred at room temperature for 3 hrs. The resulting mixture was concentrated under reduced pressure to give a crude solid that was recrystallized from ethyl acetate to give the title compound.

Workup

  1. concentrationThe resulting mixture was concentrated under reduced pressure
  2. customto give a crude solid that
  3. customwas recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-85b26ffbeafb488e8565f0a2007d09f0
Source dataset
uspto-grants-2016_08
Patent number
US09403833B2

Reaction notes

Loading…