Hydrochloric Acid → HCID 86725269, compound

HRID 1478872Notes

Reaction equation

C(OC([NH:8][CH2:9][CH2:10][N:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([CH2:20][C:21]([NH:23][CH:24]([B:37]3[O:45]C4C(C)(C5CC(C4)C5(C)C)[O:38]3)[CH2:25][C:26]3[C:27](OC)=[C:28]([CH:32]=[CH:33][CH:34]=3)[C:29]([OH:31])=[O:30])=[O:22])[CH:17]=2)[CH2:12]1)=O)(C)(C)C.Cl>>[NH2:8][CH2:9][CH2:10][N:11]1[CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([CH2:20][C:21]([NH:23][C@H:24]3[CH2:25][C:26]4[CH:34]=[CH:33][CH:32]=[C:28]([C:29]([OH:31])=[O:30])[C:27]=4[O:45][B:37]3[OH:38])=[O:22])[CH:17]=2)[CH2:12]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86725268HCID 86725268, compound

Product 1

HCID 86725269HCID 86725269, compound

Procedure

Prepared from 3-[2-{2-[2-(2-tert-Butoxycarbonylamino-ethyl)-2,3-dihydro-1H-isoindol-5-yl]-acetylamino}-2-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)-ethyl]-2-methoxy-benzoic acid and HCl following the procedure described in Step 6 of Example 48. The crude product was purified by reverse phase preparative HPLC and dried using lyophilization. ESI-MS m/z 410 (MH)+.

Workup

customThe crude product was purified by reverse phase preparative HPLC
customdried

Sources & evidence

ORD record: ord-0b56b6f9d936462dafb75459fb25bc8b
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09403850B2

Reaction notes

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