Hydrochloric Acid → HCID 86725272, compound

HRID 1478878Notes

Reaction equation

C(OC([N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][C:12]([CH2:18][C:19](=[O:51])[NH:20][CH:21]([B:38]3[O:46]C4C(C)(C5CC(C4)C5(C)C)[O:39]3)[CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([O:31]C(C)(C)C)=[O:30])[C:24]=3OC)=[CH:13][CH:14]=2)[CH2:9]1)=O)(C)(C)C.Cl>>[OH:39][B:38]1[C@@H:21]([NH:20][C:19](=[O:51])[CH2:18][C:12]2[CH:13]=[C:14]3[C:15]([CH2:16][CH2:17][NH:8][CH2:9]3)=[CH:10][CH:11]=2)[CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([C:29]([OH:31])=[O:30])[C:24]=2[O:46]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86725273HCID 86725273, compound

Product 1

HCID 86725272HCID 86725272, compound

Procedure

Prepared from 7-{[2-(3-tert-Butoxycarbonyl-2-methoxy-phenyl)-1-(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)-ethylcarbamoyl]-methyl}-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester and HCl following the procedure described in Step 6 of Example 48. The crude product was purified by reverse phase preparative HPLC and dried using lyophilization. ESI-MS m/z 381 (MH)+.

Workup

customThe crude product was purified by reverse phase preparative HPLC
customdried

Sources & evidence

ORD record: ord-dc2cbe72ec084d26864d4825bbef0eae
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09403850B2

Reaction notes

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