反应详情

A 4M solution of HCl in 1,4-dioxane (35 mL; 140 mmol; 23.7 eq.) was added to 6-bromo-1H,3H-2,4,7a,8-tetraaza-cyclopenta[a]indene-2-carboxylic acid tert-butyl ester (2 g; 5.9 mmol; 1 eq.) and the resulting mixture was stirred at room temperature for 18 hours. The precipitate was filtered off, washed with Et2O and dried to afford the title compound (1.56 g, 96%) as beige solid. 1H NMR (DMSO-d6) δ 10.61 (br s, 2H), 9.68 (d, J=2.2 Hz, 1H), 8.69 (d, J=2.2 Hz, 1H), 4.56 (s, 4H). UPLC/MS: (MS+) 239.1 and 241.1 ([M+H]+).

1. filtrationThe precipitate was filtered off
2. washwashed with Et2O
3. customdried