反应详情

A suspension of 2-nitro-4-bromoaniline (5 g, 23 mmol) in toluene is admixed with 3.27 g (23 mmol) of 2-naphthylboronic acid, 9.5 g (0.069 mol) of potassium carbonate and 1.3 g of tetrakis(triphenylphosphine)palladium. The mixture is heated to reflux for 4 hours and the reaction is stopped by adding 100 ml of water. The mixture is extracted with ethyl acetate and dried over sodium sulphate, and the solvent is removed under reduced pressure. Purification by column chromatography gives 4.1 g (68% yield).

1. temperatureThe mixture is heated
2. temperatureto reflux for 4 hours
3. extractionThe mixture is extracted with ethyl acetate
4. dry with materialdried over sodium sulphate
5. customthe solvent is removed under reduced pressure
6. customPurification by column chromatography
7. customgives 4.1 g (68% yield)