3-Chlorophenethylamine → N-(3-{2-[2-(3-Chloro-phenyl)-ethylamino]-pyrimidin-4-yl}-benzyl)-N-piperidin-4-yl-methanesulfonamide

関与物質

役割	名称	HCID	仕込み量
反応物	3-Chlorophenethylamine	HCID 139381	—
反応物	4-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-methanesulfonyl-amino}-piperidine-1-carboxylic acid tert-butyl ester	HCID 86603264	—
生成物	N-(3-{2-[2-(3-Chloro-phenyl)-ethylamino]-pyrimidin-4-yl}-benzyl)-N-piperidin-4-yl-methanesulfonamide	HCID 58603707	—

反応手順

Intermediate 30 was coupled with 2-(3-chloro-phenyl)-ethylamine following procedure F and the resulting product deprotected following procedure G. LC-MS showed the product had the expected M+H+ of 500. 1H NMR (Varian 300 MHz, CD3OD, shifts relative to the solvent peak at 3.3 ppm) δ 8.3 (d, 1H), 8.1 (d, 1H) 7.7 (d, 1H) 7.5 (t, 1H), 7.3 (m, 2H), 7.25 (m, 3H), 7.20 (d, 1H), δ 4.6 (s, 2H), δ 3.3 (t, 2H), 3.09 (s, 3H), δ 3.04 (m, 7H), 2.0 (m, 4H).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07732444B2
出典データセット	uspto-grants-2010_06
ORD ID	ord-d3714c55291345d9a85a9e566d7b60d1
出典メモ	uspto-grants-2010_06