HRID1479310

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：CCCCC/C=C\C/C=C\CCCCCCCC(=O)O$

HCID5280450

Linoleic acid

C18H32O2

结构：CC(C)(C)OC(=O)N1C[C@@H](CO)[C@H](CO)C1

HCID59512458

未命名化合物

PRODUCTS

生成物

$结构：CCCCC/C=C\C/C=C\CCCCCCCC(=O)OC[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1COC(=O)CCCCCCC/C=C\C/C=C\CCCCC$

HCID86682226

未命名化合物

PROCEDURE

实验过程

Compound XIII-2 (351 mg, 71.7%) was obtained in the same manner as that in Reference Example 2, by using trans-3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester (150 mg, 0.674 mmol) obtained by using the method described in WO2006/100036 and linoleic acid (Aldrich; 400 mg, 1.48 mmol)

WORKUP

后处理

customCompound XIII-2 (351 mg, 71.7%) was obtained in the same manner as that in Reference Example 2
customobtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c53374646f324d0e886566f973f507db
来源数据集: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09408914B2
来源说明: uspto-grants-2016_08

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:12][C@@H:11]([CH2:13][OH:14])[C@H:10]([CH2:15][OH:16])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:17]([OH:36])(=O)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]/[CH:25]=[CH:26]\[CH2:27]/[CH:28]=[CH:29]\[CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>>[C:1]([O:5][C:6]([N:8]1[CH2:9][C@@H:10]([CH2:15][O:16][C:17](=[O:36])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]/[CH:25]=[CH:26]\[CH2:27]/[CH:28]=[CH:29]\[CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[C@H:11]([CH2:13][O:14][C:17](=[O:36])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]/[CH:25]=[CH:26]\[CH2:27]/[CH:28]=[CH:29]\[CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH2:12]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]