HuagongsheHuagongshe Chemistry Print Report · For research reference only
Linoleic Acid → Trans-1-(tert-butoxycarbonyl)-3,4-bis(((9Z,12Z)-octadeca-9,12-dienoyloxy)methyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Linoleic Acid | HCID 5280450 | — |
| Reactant | (3S,4S)-tert-Butyl 3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylate | HCID 59512458 | — |
| Product | Trans-1-(tert-butoxycarbonyl)-3,4-bis(((9Z,12Z)-octadeca-9,12-dienoyloxy)methyl)pyrrolidine | HCID 86682226 | — |
Reaction Steps
Compound XIII-2 (351 mg, 71.7%) was obtained in the same manner as that in Reference Example 2, by using trans-3,4-bis(hydroxymethyl)pyrrolidine-1-carboxylic acid tert-butyl ester (150 mg, 0.674 mmol) obtained by using the method described in WO2006/100036 and linoleic acid (Aldrich; 400 mg, 1.48 mmol)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09408914B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-c53374646f324d0e886566f973f507db |
| Source note | uspto-grants-2016_08 |