N,N-Dimethylglycine hydrochloride → HCID 86682227, compound

HRID 1479314Notes

Reaction equation

HRID 1479314 reaction equation
[C:1]([O:20][C@H:21]1[C@H:25]([O:26][C:27](=[O:45])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]/[CH:35]=[CH:36]\[CH2:37]/[CH:38]=[CH:39]\[CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH2:24][NH:23][CH2:22]1)(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11]/[CH:12]=[CH:13]\[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].Cl.[CH3:47][N:48]([CH3:53])[CH2:49][C:50](O)=[O:51]>>[C:1]([O:20][C@H:21]1[C@H:25]([O:26][C:27](=[O:45])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34]/[CH:35]=[CH:36]\[CH2:37]/[CH:38]=[CH:39]\[CH2:40][CH2:41][CH2:42][CH2:43][CH3:44])[CH2:24][N:23]([C:50](=[O:51])[CH2:49][N:48]([CH3:53])[CH3:47])[CH2:22]1)(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11]/[CH:12]=[CH:13]\[CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 75605N,N-Dimethylglycine hydrochlorideHCID 86682228HCID 86682228, compound

Product 1

HCID 86682227HCID 86682227, compound

Procedure

Compound 26 (297 mg, 87.2%) was obtained in the same manner as that in Example 25, by using compound 2 (300 mg, 0.478 mmol) obtained in Example 2, and N,N-dimethylglycine hydrochloride (Tokyo Chemical Industry Co., Ltd.; 133 mg, 0.955 mmol).

Sources & evidence

ORD record
ord-b122ced1f1a642c5af5bbb06916f7073
Source dataset
uspto-grants-2016_08
Patent number
US09408914B2

Reaction notes

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