反应详情

A solution of 3-(benzyloxy)-5-bromopyridine (from step 1) (1.0 eq.) and meta-chloroperbenzoic acid (mCPBA) (4.0 eq.) in dichloromethane (0.1 M) was stirred at room temperature for 18 hours. The reaction was quenched with saturated aqueous NaHCO3 solution and extracted with dichloromethane three times. The combined organic layers were dried over anhydrous MgSO4 and concentrated en vacuo. The crude residue was purified by a COMBIFLASH® system (ISCO) using 0-100% ethyl acetate in hexane to give 3-(benzyloxy)-5-bromopyridine 1-oxide.

1. customThe reaction was quenched with saturated aqueous NaHCO3 solution
2. extractionextracted with dichloromethane three times
3. dry with materialThe combined organic layers were dried over anhydrous MgSO4
4. concentrationconcentrated en vacuo
5. customThe crude residue was purified by a COMBIFLASH® system (ISCO)