Thionyl Chloride → HCID 86652358, compound

HRID 1479621Notes

Reaction equation

HRID 1479621 reaction equation
[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8]([CH2:12][CH2:13][C:14]3[CH:22]=[CH:21][C:17]([C:18](O)=[O:19])=[CH:16][C:15]=3[CH3:23])=[CH:7][C:6]=2[C:5]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:4]=2[N:3]=1.S(Cl)([Cl:31])=O>>[NH2:1][C:2]1[C:11]2[N:10]=[CH:9][C:8]([CH2:12][CH2:13][C:14]3[CH:22]=[CH:21][C:17]([C:18]([Cl:31])=[O:19])=[CH:16][C:15]=3[CH3:23])=[CH:7][C:6]=2[C:5]2[CH:24]=[CH:25][C:26]([CH3:28])=[CH:27][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 58213539HCID 58213539, compound

Product 1

HCID 86652358HCID 86652358, compound

Procedure

A solution of 4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylbenzoic acid (from the previous step) in thionyl chloride was stirred at 60° C. for 3 hour. After cooling to ambient temperature, the reaction mixture was concentrated en vaccuo. The crude material was used for next step without purification.

Workup

  1. concentrationthe reaction mixture was concentrated en vaccuo
  2. customThe crude material was used for next step without purification

Sources & evidence

ORD record
ord-030bb7bfadef40d197d26726f45b6cfc
Source dataset
uspto-grants-2016_08
Patent number
US09408907B2

Reaction notes

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