Sodium Hydroxide → HCID 24260487, compound

Temperature

0 °C

To a solution of 3-(4-bromophenyl)butanamide (0.60 g, 2.48 mmol) in anhydrous tetrahydrofuran (15 mL) was added Lithium aluminum hydride (0.14 g, 37.2 mmol), the mixture was stirred at reflux for 1.5 hours, after the completion of the reaction, the mixture was cooled to 0° C., 1N sodium hydroxide solution (10 mL) was added slowly, after the reaction, the mixture was stirred at room temperature for 15 minutes. The mixture was filtered and the filtration was collected and extracted with ethyl acetate (10 mL×3), the organic phase was collected and dried over sodium sulfate, removed the solvent under reduce pressure to give 3-(4-bromophenyl)butan-1-amine as a pale yellow oil (0.57 g, 100%) which could be used in the next step without further purification. LR S (M+H+) m/z: calcd for 228.13. found 228.

1. temperatureat reflux for 1.5 hours
2. customafter the completion of the reaction
3. customafter the reaction
4. stirringthe mixture was stirred at room temperature for 15 minutes
5. filtrationThe mixture was filtered
6. filtrationthe filtration
7. customwas collected
8. extractionextracted with ethyl acetate (10 mL×3)
9. customthe organic phase was collected
10. dry with materialdried over sodium sulfate
11. customremoved the solvent

ORD record

ord-5a4260aad8714ca78bb3561d96e6b13c

Source dataset

uspto-grants-2016_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09409865B2