2-Fluoro-4-(trifluoromethyl)benzoyl chloride → HCID 68372404, compound

HRID 1479795Notes

Reaction equation

HRID 1479795 reaction equation
Br[C:2]1[C:11]([CH3:12])=[C:10]([O:13][CH3:14])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[O:15][CH3:16].[F:17][C:18]1[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:19]=1[C:20](Cl)=[O:21]>C1CCCCC1.CCOC(C)=O>[CH3:16][O:15][C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:10]([O:13][CH3:14])=[C:11]([CH3:12])[C:2]=1[C:20]([C:19]1[CH:23]=[CH:24][C:25]([C:27]([F:28])([F:29])[F:30])=[CH:26][C:18]=1[F:17])=[O:21]

Participants

4

Reactant 2

HCID 1455802-Fluoro-4-(trifluoromethyl)benzoyl chlorideHCID 2922402-Bromo-1,4-dimethoxy-3-methylnaphthalene

Product 1

HCID 68372404HCID 68372404, compound

Reagents, catalysts & solvents 1

HCID 21867204Cyclohexane ethylacetateSolvent

Procedure

2-bromo-1.4-dimethoxy-3-methylnaphthalene (300 mg, 1.07 mmol) and commercially available 2-fluoro-4-trifluoromethyl-benzoylchloride (265 mg. 1.17 mmol) were treated according to general procedure 12.1. The resulting yellow oil was purified through flash chromatography (Cyclohexane:EtOAc 10:1). The product was obtained as a yellow oil. Rf(Cyclohexane:EtOAc 10:1)=0.50. Yield=175 mg (42%).

Workup

  1. customThe resulting yellow oil was purified through flash chromatography (Cyclohexane:EtOAc 10:1)
  2. customThe product was obtained as a yellow oil

Sources & evidence

ORD record
ord-2e3e679b3c724896baefcd848282073b
Source dataset
uspto-grants-2016_08
Patent number
US09409879B2

Reaction notes

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