HCID 68372404, compound → HCID 70810769, compound

HRID 1479797Notes

Reaction equation

HRID 1479797 reaction equation
C[O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13][CH3:14])=[C:5]([CH3:15])[C:4]=1[C:16]([C:18]1[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][C:19]=1[F:28])=[O:17]>C(Cl)Cl.C1CCCCC1>[F:28][C:19]1[CH:20]=[C:21]([C:24]([F:25])([F:27])[F:26])[CH:22]=[CH:23][C:18]=1[C:16]([C:4]1[C:5]([CH3:15])=[C:6]([O:13][CH3:14])[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[OH:2])=[O:17]

Participants

3

Reactant 1

HCID 68372404HCID 68372404, compound

Product 1

HCID 70810769HCID 70810769, compound

Reagents, catalysts & solvents 1

HCID 21916607Dichloromethane cyclohexaneSolvent

Procedure

(1,4-dimethoxy-3-methylnaphthalen-2-yl)(2-fluoro-4-(trifluoromethyl) phenyl)methanone LJ123 (23 mg, 0.060 mmol) was used as a starting material and treated according to general procedure 12.1. The resulting yellow oil was purified through flash chromatography (DCM:Cyclohexane 1:1). The product was obtained as a yellow solid. Rf(DCM:Cyclohexane 1:1)=0.55. Yield=15 mg (68%).

Workup

  1. additiontreated
  2. customThe resulting yellow oil was purified through flash chromatography (DCM:Cyclohexane 1:1)
  3. customThe product was obtained as a yellow solid

Sources & evidence

ORD record
ord-d5fda68addbe43998c85ac57c0ad05c3
Source dataset
uspto-grants-2016_08
Patent number
US09409879B2

Reaction notes

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