Hydrochloric Acid → HCID 67179051, compound

HRID 1479958Notes

Reaction equation

HRID 1479958 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]([N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][C@H:12]2[CH3:24])=[N:9][CH:10]=1)=[O:4].Cl>CO>[CH3:1][O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][C@H:12]2[CH3:24])=[N:9][CH:10]=1)=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67179448HCID 67179448, compound

Product 1

HCID 67179051HCID 67179051, compoundYield 85.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
70 °C

Procedure

To a solution of (R)-2-methyl-4-boc-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl-5′-carboxylic acid methyl ester (2 g, 5.94 mmol) in MeOH (17 mL) is added HCl (4M in dioxane, 4.5 mL, 18 mmol). The reaction mixture is stirred at 70° C. for 1 h. The reaction solution is concentrated, dissolved in DCM and organic layer is washed with Na2CO3 to adjust the pH value to 8.0. The solvents are removed under reduced pressure to afford a brown oil (1.2 g, 77%).

Workup

  1. concentrationThe reaction solution is concentrated
  2. dissolutiondissolved in DCM
  3. washorganic layer is washed with Na2CO3
  4. customThe solvents are removed under reduced pressure

Sources & evidence

ORD record
ord-16070bc793b74381a3c22764f2db288c
Source dataset
uspto-grants-2016_08
Patent number
US09409871B2

Reaction notes

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