Methyl 5-chloropyrazine-2-carboxylate → HCID 59191557, compound

HRID 1479965Notes

Reaction equation

HRID 1479965 reaction equation
[CH3:1][C:2]1[C:7]([CH3:8])=[C:6]([CH2:9][C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[N:5]=[N:4][C:3]=1[N:16]1[CH2:21][CH2:20][NH:19][C@H:18]([CH3:22])[CH2:17]1.[CH3:23][O:24][C:25]([C:27]1[CH:32]=[N:31][C:30](Cl)=[CH:29][N:28]=1)=[O:26]>>[CH3:23][O:24][C:25]([C:27]1[N:28]=[CH:29][C:30]([N:19]2[CH2:20][CH2:21][N:16]([C:3]3[N:4]=[N:5][C:6]([CH2:9][C:10]4[CH:11]=[CH:12][N:13]=[CH:14][CH:15]=4)=[C:7]([CH3:8])[C:2]=3[CH3:1])[CH2:17][C@H:18]2[CH3:22])=[N:31][CH:32]=1)=[O:26]

Participants

3

Reactant 2

HCID 406081Methyl 5-chloropyrazine-2-carboxylateHCID 59191468HCID 59191468, compound

Product 1

HCID 59191557HCID 59191557, compoundYield 56%

Procedure

According to the protocol described below for example 46, 4,5-dimethyl-3-((R)-3-methylpiperazin-1-yl)-6-pyridin-4-ylmethyl-pyridazine (155 mg, 0.51 mmol) and 5-chloro-pyrazine-2-carboxylic acid methyl ester (99 mg, 0.56 mmol) afforded the title compound as an orange oil (123 mg, 56%).

Sources & evidence

ORD record
ord-1a8b56ce42c0436894aac4b6e2bc875a
Source dataset
uspto-grants-2016_08
Patent number
US09409871B2

Reaction notes

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