Leucinamide → 5-Chloro-4-(3-chloro-phenyl)-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide

HRID 1480039Notes

Reaction equation

HRID 1480039 reaction equation
[Cl:1][C:2]1[C:3]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:18][C@@H:19]([CH2:23][CH:24]([CH3:26])[CH3:25])[C:20]([NH2:22])=[O:21]>>[C:20]([C@@H:19]([NH:18][C:8]([C:5]1[CH:4]=[C:3]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])[CH2:23][CH:24]([CH3:26])[CH3:25])(=[O:21])[NH2:22]

Participants

3

Reactant 2

HCID 69640LeucinamideHCID 902037665-Chloro-4-(3-chlorophenyl)-pyridine-2-carboxylic acid

Product 1

HCID 762819975-Chloro-4-(3-chloro-phenyl)-pyridine-2-carboxylic acid ((S)-1-carbamoyl-3-methyl-butyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-(3-chlorophenyl)-pyridine-2-carboxylic acid and (2S)-2-amino-4-methyl-pentanamide (CAN 687-51-4) as starting materials and isolated (8 mg, 21%) as colorless oil; MS (ESI, m/z): 380.1, 382.1 (MH+).

Workup

  1. customisolated (8 mg, 21%) as colorless oil

Sources & evidence

ORD record
ord-a5923f24290c4cce9901509cc71cfc7c
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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