R-2-Amino-2,3-dimethyl-butan-1-OL → 5-Chloro-4-(4-fluoro-benzyl)-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-1,2-dimethyl-propyl)-amide

HRID 1480060노트

반응식

HRID 1480060 반응식
[Cl:1][C:2]1[C:3]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:19][C@:20]([CH3:26])([CH:23]([CH3:25])[CH3:24])[CH2:21][OH:22]>>[OH:22][CH2:21][C@@:20]([NH:19][C:8]([C:5]1[CH:4]=[C:3]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])([CH3:26])[CH:23]([CH3:25])[CH3:24]

참가 물질

3

반응물 2

HCID 12113027R-2-Amino-2,3-dimethyl-butan-1-OLHCID 902041245-Chloro-4-(4-fluorobenzyl)-pyridine-2-carboxylic acid

생성물 1

HCID 762824805-Chloro-4-(4-fluoro-benzyl)-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-1,2-dimethyl-propyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 1, using 5-chloro-4-(4-fluorobenzyl)-pyridine-2-carboxylic acid and (2R)-2-amino-2,3-dimethyl-1-butanol (CAN 155158-75-1) as starting materials and isolated (29 mg, 25%) as colorless oil; LC-MS (UV peak area, m/z) 100%, 365.1428 (MH+).

후처리

  1. customisolated (29 mg, 25%) as colorless oil

출처 및 근거

ORD 기록
ord-885d0b3adce5418f87eaf92be15c8a31
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409866B2

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