HuagongsheHuagongshe Chemistry Print Report · For research reference only
R-2-Amino-2,3-dimethyl-butan-1-OL → 5-Chloro-4-(4-fluoro-benzyl)-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-1,2-dimethyl-propyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | R-2-Amino-2,3-dimethyl-butan-1-OL | HCID 12113027 | — |
| Reactant | 5-Chloro-4-(4-fluorobenzyl)-pyridine-2-carboxylic acid | HCID 90204124 | — |
| Product | 5-Chloro-4-(4-fluoro-benzyl)-pyridine-2-carboxylic acid ((R)-1-hydroxymethyl-1,2-dimethyl-propyl)-amide | HCID 76282480 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 5-chloro-4-(4-fluorobenzyl)-pyridine-2-carboxylic acid and (2R)-2-amino-2,3-dimethyl-1-butanol (CAN 155158-75-1) as starting materials and isolated (29 mg, 25%) as colorless oil; LC-MS (UV peak area, m/z) 100%, 365.1428 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-885d0b3adce5418f87eaf92be15c8a31 |
| Source note | uspto-grants-2016_08 |