HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amine → HCID 123319424, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoro-1-(pyridin-2-yl)ethan-1-amine | HCID 25219911 | — |
| Reactant | 5-Chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 90203638 | — |
| Product | HCID 123319424 | HCID 123319424 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 5-chloro-4-cyclopropylmethoxy-pyridine-2-carboxylic acid and α-(trifluoromethyl)-2-pyridinemethanamine (CAN 503173-14-6) as starting materials. The racemate (96 mg, 83%) was separated into its enantiomers by preparative chiral HPLC (ChiralPak AD, isopropanol/heptane) and the title compound was isolated as colorless oil; LC-MS (UV peak area, m/z) 100%, 386.0882 (MH+). [α]D20=+22.4 (MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-adb718468c3e4641945345cc4d5d7ff0 |
| Source note | uspto-grants-2016_08 |