2,2-Dimethyl-1-thiazol-2-yl-propylamine → 5-Chloro-4-(oxetan-3-yloxy)-pyridine-2-carboxylic acid (2,2-dimethyl-1-thiazol-2-yl-propyl)-amide

HRID 1480083Notes

Reaction equation

HRID 1480083 reaction equation
[Cl:1][C:2]1[C:3]([O:11][CH:12]2[CH2:15][O:14][CH2:13]2)=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH3:16][C:17]([CH3:26])([CH3:25])[CH:18]([NH2:24])[C:19]1[S:20][CH:21]=[CH:22][N:23]=1>>[CH3:16][C:17]([CH3:26])([CH3:25])[CH:18]([NH:24][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH:12]2[CH2:15][O:14][CH2:13]2)[C:2]([Cl:1])=[CH:7][N:6]=1)=[O:10])[C:19]1[S:20][CH:21]=[CH:22][N:23]=1

Participants

3

Reactant 2

HCID 207955242,2-Dimethyl-1-thiazol-2-yl-propylamineHCID 902034755-Chloro-4-(oxetan-3-yloxy)-pyridine-2-carboxylic acid

Product 1

HCID 762832135-Chloro-4-(oxetan-3-yloxy)-pyridine-2-carboxylic acid (2,2-dimethyl-1-thiazol-2-yl-propyl)-amide

Procedure

The title compound was synthesized in analogy to Example 24d, using 5-Chloro-4-(oxetan-3-yloxy)-pyridine-2-carboxylic acid (Example 23a) and 2,2-Dimethyl-1-thiazol-2-yl-propylamine (CAN 1247122-26-4) as starting materials and isolated (21.6 mg, 37%) as white solid; MS (ESI, m/z): 382.3 (M+H+).

Workup

  1. customisolated (21.6 mg, 37%) as white solid

Sources & evidence

ORD record
ord-919488c561234190a57b1e63d7c456f1
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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