HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Dimethyl-1-thiazol-2-yl-propylamine → 5-Chloro-4-(oxetan-3-yloxy)-pyridine-2-carboxylic acid (2,2-dimethyl-1-thiazol-2-yl-propyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Dimethyl-1-thiazol-2-yl-propylamine | HCID 20795524 | — |
| Reactant | 5-Chloro-4-(oxetan-3-yloxy)-pyridine-2-carboxylic acid | HCID 90203475 | — |
| Product | 5-Chloro-4-(oxetan-3-yloxy)-pyridine-2-carboxylic acid (2,2-dimethyl-1-thiazol-2-yl-propyl)-amide | HCID 76283213 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 24d, using 5-Chloro-4-(oxetan-3-yloxy)-pyridine-2-carboxylic acid (Example 23a) and 2,2-Dimethyl-1-thiazol-2-yl-propylamine (CAN 1247122-26-4) as starting materials and isolated (21.6 mg, 37%) as white solid; MS (ESI, m/z): 382.3 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-919488c561234190a57b1e63d7c456f1 |
| Source note | uspto-grants-2016_08 |