4-Fluorobenzyl bromide → 2,5-Dichloro-4-(4-fluoro-benzyloxy)-pyridine

HRID 1480084Notes

Reaction equation

HRID 1480084 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([OH:8])[C:5]([Cl:9])=[CH:4][N:3]=1.Br[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([O:8][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[C:5]([Cl:9])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 680214-Fluorobenzyl bromideHCID 178516192HCID 178516192, compound

Product 1

HCID 902032662,5-Dichloro-4-(4-fluoro-benzyloxy)-pyridine

Procedure

The title compound was synthesized in analogy to Example 12a, using 2,5-dichloro-4-pyridinol (CAN 847664-65-7) and 1-(bromomethyl)-4-fluoro-benzene (CAN 459-46-1) as starting materials and isolated (1.03 g, 62%) as white solid; LC-MS (UV peak area, m/z) 98.6%, 272.0040 (MH+).

Workup

  1. customisolated (1.03 g, 62%) as white solid

Sources & evidence

ORD record
ord-38e42d523a234b33be1164532d9ce54d
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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