HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2,2,2-Trifluoro-1-(pyridin-3-YL)ethanamine hydrochloride → 5-Chloro-4-(4-fluoro-benzyloxy)-pyridine-2-carboxylic acid ((S)-2,2,2-trifluoro-1-pyridin-3-yl-ethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2,2,2-Trifluoro-1-(pyridin-3-YL)ethanamine hydrochloride | HCID 51358484 | — |
| Reactant | 5-Chloro-4-(4-fluoro-benzyloxy)-pyridine-2-carboxylic acid | HCID 90203562 | — |
| Product | 5-Chloro-4-(4-fluoro-benzyloxy)-pyridine-2-carboxylic acid ((S)-2,2,2-trifluoro-1-pyridin-3-yl-ethyl)-amide | HCID 76282723 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 12d, using 5-chloro-4-(4-fluoro-benzyloxy)-pyridine-2-carboxylic acid and (αS)-α-(trifluoromethyl)-3-pyridinemethanamine hydrochloride (1:1) (CAN 749839-26-7) as starting materials and isolated (26 mg, 83%) as colorless oil; MS (ESI, m/z): 440.3 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-d7fa0cfa06714077bb324cd9af0cb1d1 |
| Source note | uspto-grants-2016_08 |