HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-Amino-N,3,3-trimethylbutanamide → 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-Amino-N,3,3-trimethylbutanamide | HCID 445856 | — |
| Reactant | 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid | HCID 90203674 | — |
| Product | 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid ((S)-2,2-dimethyl-1-methylcarbamoyl-propyl)-amide | HCID 76282720 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 24d, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and (S)-2-amino-N,3,3-trimethylbutanamide (CAN 89226-12-0) as starting materials and isolated (115 mg, 52%) as a white solid; MS (ESI, m/z): 388.5 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-53df378b94a44798af3db49a09323324 |
| Source note | uspto-grants-2016_08 |