2-Propanol, 1-amino-2-methyl- → HCID 76283954, compound

HRID 1480116Notes

Reaction equation

HRID 1480116 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH2:19][CH2:20][C:21]([CH3:24])([OH:23])[CH3:22]>>[OH:23][C:21]([CH3:24])([CH3:22])[CH2:20][NH:19][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12]

Participants

3

Reactant 2

HCID 951022-Propanol, 1-amino-2-methyl-HCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 76283954HCID 76283954, compound

Procedure

The title compound was synthesized in analogy to Example 24d, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 1-amino-2-methylpropan-2-ol (CAN 2854-16-2) as starting materials and isolated (28 mg, 34%) as a yellow oil; MS (ESI, m/z): 333.5 (M+H+).

Workup

  1. customisolated (28 mg, 34%) as a yellow oil

Sources & evidence

ORD record
ord-769f7c408d224153b950096d808326e5
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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