2-Oxa-5-azaspiro[3.4]octane oxalate → HCID 90203652, compound

HRID 1480132Notes

Reaction equation

HRID 1480132 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.C(O)(=O)C(O)=O.[CH2:25]1[C:28]2([CH2:32][CH2:31][CH2:30][NH:29]2)[CH2:27][O:26]1>>[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([N:29]3[CH2:30][CH2:31][CH2:32][C:28]43[CH2:25][O:26][CH2:27]4)=[O:12])=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 722073532-Oxa-5-azaspiro[3.4]octane oxalateHCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 90203652HCID 90203652, compound

Procedure

The title compound was synthesized in analogy to Example 63b, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 2-Oxa-5-aza-spiro[3.4]octane oxalate (CAN 1380571-82-3) as starting materials and isolated (37.6 mg, 46%) as colorless oil; MS (ESI, m/z): 357.1 (M+H+).

Workup

  1. customisolated (37.6 mg, 46%) as colorless oil

Sources & evidence

ORD record
ord-ab3dcebde17246d79d0b90b70b962f8e
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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