5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid → HCID 76283952, compound

HRID 1480136Notes

Reaction equation

HRID 1480136 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.Cl.[CH3:20][C:21]([NH:27]C)([CH2:25][CH3:26])[C:22]([NH2:24])=[O:23]>>[C:22]([C:21]([NH:27][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])([CH3:20])[CH2:25][CH3:26])(=[O:23])[NH2:24]

Participants

3

Reactant 2

HCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acidHCID 90203860HCID 90203860, compound

Product 1

HCID 76283952HCID 76283952, compound

Procedure

The title compound was synthesized in analogy to Example 63b, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 2-Methyl-2-methylamino-butyramide hydrochloride (CAN 18305-22-1) as starting materials and isolated (19.6 mg, 16%) as a white solid; MS (ESI, m/z): 360.5 (M+H+).

Workup

  1. customisolated (19.6 mg, 16%) as a white solid

Sources & evidence

ORD record
ord-9f83da892f994a9c83b1cb853d56e0e3
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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