2,2,2-Trifluoroethanol → HCID 84708639, compound

HRID 1480137Notes

Reaction equation

HRID 1480137 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1Cl.[F:9][C:10]([F:14])([F:13])[CH2:11][OH:12]>>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[O:12][CH2:11][C:10]([F:14])([F:13])[F:9]

Participants

3

Reactant 2

HCID 64092,2,2-TrifluoroethanolHCID 8176963-Bromo-4-chloropyridine

Product 1

HCID 84708639HCID 84708639, compound

Procedure

The title compound was synthesized in analogy to Example 53a, using 3-bromo-4-chloropyridine (CAN 36953-42-1) and 2,2,2-trifluoroethanol (CAN 75-89-8) as starting materials and isolated (7.4 g, 78%) as a yellow oil; MS (ESI, m/z): 256.1 (M+H+).

Workup

  1. customisolated (7.4 g, 78%) as a yellow oil

Sources & evidence

ORD record
ord-10dca117225345109d6b50b861f7a52e
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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