2-Amino-3-methanesulfonyl-2-methyl-propionitrile → 5-Bromo-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (1-cyano-2-methanesulfonyl-1-methyl-ethyl)-amide

HRID 1480149노트

반응식

HRID 1480149 반응식
[Br:1][C:2]1[C:3]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[NH2:17][C:18]([CH3:26])([CH2:21][S:22]([CH3:25])(=[O:24])=[O:23])[C:19]#[N:20]>>[C:19]([C:18]([NH:17][C:8]([C:5]1[CH:4]=[C:3]([O:11][CH2:12][C:13]([F:16])([F:15])[F:14])[C:2]([Br:1])=[CH:7][N:6]=1)=[O:10])([CH3:26])[CH2:21][S:22]([CH3:25])(=[O:24])=[O:23])#[N:20]

참가 물질

3

반응물 2

HCID 902033722-Amino-3-methanesulfonyl-2-methyl-propionitrileHCID 902041215-Bromo-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

생성물 1

HCID 902045995-Bromo-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (1-cyano-2-methanesulfonyl-1-methyl-ethyl)-amide

실험 절차

The title compound was synthesized in analogy to Example 78e, using 5-Bromo-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 78d) and 2-Amino-3-methanesulfonyl-2-methyl-propionitrile (Example 80a) as starting material and isolated (570 mg, 77%) as a yellow oil; MS (ESI, m/z): 444.3 (M+H+).

후처리

  1. customisolated (570 mg, 77%) as a yellow oil

출처 및 근거

ORD 기록
ord-0703143b882b4fad92b5253bf90c8be8
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09409866B2

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