3-Bromo-4-chloropyridine → HCID 90204500, compound

HRID 1480156Notes

Reaction equation

HRID 1480156 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1Cl.[F:9][C:10]([F:15])([F:14])[C@@H:11]([OH:13])[CH3:12]>>[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[O:13][C@@H:11]([CH3:12])[C:10]([F:15])([F:14])[F:9]

Participants

3

Reactant 2

HCID 8176963-Bromo-4-chloropyridineHCID 6999971(2S)-1,1,1-Trifluoropropan-2-ol

Product 1

HCID 90204500HCID 90204500, compound

Procedure

The title compound was synthesized in analogy to Example 78a, using 3-bromo-4-chloropyridine (CAN 36953-42-1) and (S)-1,1,1-trifluoropropan-2-ol (CAN 3539-97-7) as starting materials and isolated (28 g, 82%) as a yellow oil; MS (ESI, m/z): 270.4 (M+H+).

Workup

  1. customisolated (28 g, 82%) as a yellow oil

Sources & evidence

ORD record
ord-b9d6ecc61f1040df815d211b8d316c85
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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