N-tert-Butylethylamine → 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid tert-butyl-ethyl-amide

HRID 1480162Notes

Reaction equation

HRID 1480162 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][CH:15]3[CH2:17][CH2:16]3)=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH2:18]([NH:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH3:19]>>[C:21]([N:20]([CH2:18][CH3:19])[C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][CH:15]2[CH2:17][CH2:16]2)[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])([CH3:24])([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 521156N-tert-ButylethylamineHCID 902038095-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 902045905-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid tert-butyl-ethyl-amide

Procedure

The title compound was synthesized in analogy to Example 23b, using 5-Cyclopropyl-4-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42c) and N-ethyl-2-methylpropan-2-amine (CAN 4432-77-3) as starting materials and isolated (9 mg, 4.5%) as colorless oil; MS (ESI, m/z): 317.6 (M+H+).

Workup

  1. customisolated (9 mg, 4.5%) as colorless oil

Sources & evidence

ORD record
ord-dcaeecffa1a640fcb497b8390c076db5
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

Loading…