(2S)-1,1,1-Trifluoropropan-2-ol → HCID 90203925, compound

HRID 1480175Notes

Reaction equation

HRID 1480175 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[C:8]1([OH:12])[CH2:11][CH2:10][CH2:9]1.[F:13][C:14]([F:19])([F:18])[C@@H:15]([OH:17])[CH3:16]>>[F:13][C:14]([F:19])([F:18])[C@H:15]([CH3:16])[O:17][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[C:8]1([OH:12])[CH2:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 6999971(2S)-1,1,1-Trifluoropropan-2-olHCID 90203880HCID 90203880, compound

Product 1

HCID 90203925HCID 90203925, compound

Procedure

The title compound was synthesized in analogy to Example 108b, using 1-(4-Chloro-pyridin-3-yl)-cyclobutanol (Example 108a) and (S)-1,1,1-trifluoropropan-2-ol (CAN 3539-97-7) as starting materials and isolated (3.22 g, 57%) as yellow oil; MS (ESI, m/z): 262.3 (M+H+).

Workup

  1. customisolated (3.22 g, 57%) as yellow oil

Sources & evidence

ORD record
ord-2cf5d725d0a94656b124946c41e980c3
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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