HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-4,4-Difluoropyrrolidine-2-carboxamide hydrochloride → (2S)-1-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]-4,4-difluoropyrrolidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-4,4-Difluoropyrrolidine-2-carboxamide hydrochloride | HCID 45158907 | — |
| Reactant | 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid | HCID 90203674 | — |
| Product | (2S)-1-[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]-4,4-difluoropyrrolidine-2-carboxamide | HCID 76284484 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and (R)-4,4-difluoropyrrolidine-2-carboxamide hydrochloride (CAN 719267-96-6) as starting materials and isolated (33 mg, 44%); MS (ESI, m/z): 394.5 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09409866B2 |
| Source dataset | uspto-grants-2016_08 |
| ORD ID | ord-8f7766afa97f4cd3a71c7dcc547bab2e |
| Source note | uspto-grants-2016_08 |