(2S)-1,1,1-Trifluoropropan-2-ol → HCID 90214921, compound

HRID 1480193Notes

Reaction equation

HRID 1480193 reaction equation
Cl[C:2]1[C:7]([C:8]2([OH:12])[CH2:11][CH2:10][CH2:9]2)=[CH:6][N:5]=[C:4]([C:13]#[N:14])[CH:3]=1.[F:15][C:16]([F:21])([F:20])[C@@H:17]([OH:19])[CH3:18]>>[OH:12][C:8]1([C:7]2[C:2]([O:19][C@@H:17]([CH3:18])[C:16]([F:21])([F:20])[F:15])=[CH:3][C:4]([C:13]#[N:14])=[N:5][CH:6]=2)[CH2:11][CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 6999971(2S)-1,1,1-Trifluoropropan-2-olHCID 90203579HCID 90203579, compound

Product 1

HCID 90214921HCID 90214921, compound

Procedure

The title compound was synthesized in analogy to Example 123c, using 4-chloro-5-(1-hydroxycyclobutyl)pyridine-2-carbonitrile (example 126b) and (S)-1,1,1-Trifluoro-propan-2-ol (CAN 3539-97-7) as starting materials and isolated (1.2 g, 92%); MS (ESI, m/z): 287.5 (M+H+).

Workup

  1. customisolated (1.2 g, 92%)

Sources & evidence

ORD record
ord-70de42e2bd604a19affe6cbab30a2acb
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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