Hydrogen Bromide → HCID 90204569, compound

HRID 1480206Notes

Reaction equation

HRID 1480206 reaction equation
[F:1][C:2]1([C:6]2[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:8][C:9]([C:12]([OH:14])=O)=[N:10][CH:11]=2)[CH2:5][O:4][CH2:3]1.[CH3:21][C:22]1[O:26][N:25]=[C:24]([C:27]([NH2:34])([CH3:33])[CH2:28][S:29]([CH3:32])(=[O:31])=[O:30])[N:23]=1.Br>>[F:1][C:2]1([C:6]2[C:7]([O:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:8][C:9]([C:12]([NH:34][C:27]([C:24]3[N:23]=[C:22]([CH3:21])[O:26][N:25]=3)([CH3:33])[CH2:28][S:29]([CH3:32])(=[O:31])=[O:30])=[O:14])=[N:10][CH:11]=2)[CH2:3][O:4][CH2:5]1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 902034302-(5-Methyl-1,2,4-oxadiazol-3-yl)-1-methylsulfonyl-propan-2-amineHCID 90203968HCID 90203968, compound

Product 1

HCID 90204569HCID 90204569, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-(3-fluorooxetan-3-yl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxylic acid (Example 131b) and 2-(5-methyl-1,2,4-oxadiazol-3-yl)-1-methylsulfonyl-propan-2-amine;hydrobromide (enantiomer A) (example 124b) as starting materials and isolated (40 mg, 47%); MS (ESI, m/z): 497.5 (M+H+).

Workup

  1. customisolated (40 mg, 47%)

Sources & evidence

ORD record
ord-5ed0186141624b8a9437fd7e9cc2e1c2
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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