Sodium hydride → HCID 90204493, compound

HRID 1480217Notes

Reaction equation

HRID 1480217 reaction equation
Cl[C:2]1[C:7]([CH:8]2[CH2:10][CH2:9]2)=[CH:6][N:5]=[C:4]([C:11]#[N:12])[CH:3]=1.[F:13][CH:14]([F:17])[CH2:15][OH:16].[H-].[Na+]>>[CH:8]1([C:7]2[C:2]([O:16][CH2:15][CH:14]([F:17])[F:13])=[CH:3][C:4]([C:11]#[N:12])=[N:5][CH:6]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 1361872,2-Difluoroethan-1-olHCID 90203632HCID 90203632, compound

Product 1

HCID 90204493HCID 90204493, compound

Procedure

The title compound was synthesized in analogy to Example 123c, using 4-chloro-5-cyclopropyl-pyridine-2-carbonitrile (example 145b), 2,2-Difluoro-ethanol (CAN 359-13-7) as starting materials and sodium hydride as reagent. The title compound was isolated (508 mg, 81%) as a yellow solid; MS (ESI, m/z): 225.2 (M+H+).

Workup

  1. customThe title compound was synthesized in analogy to Example 123c

Sources & evidence

ORD record
ord-24935b0a90364d948615c0ddb1c62aa8
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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