5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid → HCID 90203258, compound

HRID 1480222Notes

Reaction equation

HRID 1480222 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH2:19][C:20]([C:27]1[N:31]=[C:30]([CH3:32])[O:29][N:28]=1)([CH3:26])[C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([NH:19][C:20]([C:27]3[N:31]=[C:30]([CH3:32])[O:29][N:28]=3)([CH3:26])[C:21]([O:23][CH2:24][CH3:25])=[O:22])=[O:12])=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acidHCID 90204489HCID 90204489, compound

Product 1

HCID 90203258HCID 90203258, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example 48c) and ethyl 2-amino-2-(5-methyl-1,2,4-oxadiazol-3-yl)propanoate (example 147a) as starting materials and isolated (508 mg, 86%); MS (ESI, m/z): 443.5 (M+H+).

Workup

  1. customisolated (508 mg, 86%)

Sources & evidence

ORD record
ord-2447b1653e7246a68d8fa6b2b5152614
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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