2-Amino-3-cyclopropyl-2-methyl-propionitrile → HCID 90203688, compound

HRID 1480227Notes

Reaction equation

HRID 1480227 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH2:19][C:20]([CH3:27])([CH2:23][CH:24]1[CH2:26][CH2:25]1)[C:21]#[N:22]>>[C:21]([C:20]([NH:19][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])([CH3:27])[CH2:23][CH:24]1[CH2:26][CH2:25]1)#[N:22]

Participants

3

Reactant 2

HCID 847160492-Amino-3-cyclopropyl-2-methyl-propionitrileHCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 90203688HCID 90203688, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 2-Amino-3-cyclopropyl-2-methyl-propionitrile (example 66a) as starting materials and isolated (376 mg, 67%); MS (ESI, m/z): 368.6 (M+H+).

Workup

  1. customisolated (376 mg, 67%)

Sources & evidence

ORD record
ord-57f5ff5f666441cd8f48ea958d0e2fe9
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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