Dimethylamine, hydrochloride → HCID 90203980, compound

HRID 1480252Notes

Reaction equation

[CH:1]1([C:4]2[C:5]([O:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[CH:6][C:7]([C:10]([NH:12][C:13]([C:18]3[N:22]=[C:21]([CH3:23])[O:20][N:19]=3)([CH3:17])[C:14]([OH:16])=O)=[O:11])=[N:8][CH:9]=2)[CH2:3][CH2:2]1.Cl.[CH3:31][NH:32][CH3:33]>>[CH:1]1([C:4]2[C:5]([O:24][CH2:25][C:26]([F:27])([F:29])[F:28])=[CH:6][C:7]([C:10]([NH:12][C:13]([C:18]3[N:22]=[C:21]([CH3:23])[O:20][N:19]=3)([CH3:17])[C:14]([N:32]([CH3:33])[CH3:31])=[O:16])=[O:11])=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

Reactant 2

HCID 10473Dimethylamine, hydrochloride

HCID 90203702HCID 90203702, compound

Product 1

HCID 90203980HCID 90203980, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 2-[[5-cyclopropyl-4-(2,2,2-trifluoroethoxy)pyridine-2-carbonyl]amino]-2-(5-methyl-1,2,4-oxadiazol-3-yl)propanoic acid (example 147c) and dimethylamine hydrochloride as starting materials and isolated (23 mg, 51%); MS (ESI, m/z): 442.5 (M+H+).

Workup

customisolated (23 mg, 51%)

Sources & evidence

ORD record: ord-70e858e270de4524b0f0bf4b94bbd4ea
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09409866B2

Reaction notes

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