HCID 90204489, compound → HCID 90214978, compound

HRID 1480254Notes

Reaction equation

HRID 1480254 reaction equation
[F:1][C:2]1([C:6]2[C:7]([O:15][C@@H:16]([CH3:21])[C:17]([F:20])([F:19])[F:18])=[CH:8][C:9]([C:12](O)=[O:13])=[N:10][CH:11]=2)[CH2:5][O:4][CH2:3]1.[NH2:22][C:23]([C:30]1[N:34]=[C:33]([CH3:35])[O:32][N:31]=1)([CH3:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[F:1][C:2]1([C:6]2[C:7]([O:15][C@@H:16]([CH3:21])[C:17]([F:18])([F:19])[F:20])=[CH:8][C:9]([C:12]([NH:22][C:23]([C:30]3[N:34]=[C:33]([CH3:35])[O:32][N:31]=3)([CH3:29])[C:24]([O:26][CH2:27][CH3:28])=[O:25])=[O:13])=[N:10][CH:11]=2)[CH2:5][O:4][CH2:3]1

Participants

3

Reactant 2

HCID 90204489HCID 90204489, compoundHCID 902149505-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid

Product 1

HCID 90214978HCID 90214978, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-(3-fluorooxetan-3-yl)-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carboxylic acid (example 142b) and ethyl 2-amino-2-(5-methyl-1,2,4-oxadiazol-3-yl)propanoate (example 147a) as starting materials and isolated (283 mg, purity: 86%, 57%); MS (ESI, m/z): 491.5 (M+H+).

Workup

  1. customisolated (283 mg, purity: 86%, 57%)

Sources & evidence

ORD record
ord-879527ae04874eb69fa13e49b2d9fa66
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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