5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid → HCID 90203565, compound

HRID 1480258Notes

Reaction equation

HRID 1480258 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH2:19][C:20]([CH3:32])([CH2:28][CH:29]1[CH2:31][CH2:30]1)[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22]>>[CH:29]1([CH2:28][C:20]([NH:19][C:10]([C:7]2[CH:6]=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]3[CH2:2][CH2:3]3)=[CH:9][N:8]=2)=[O:12])([CH3:32])[C:21]([O:23][C:24]([CH3:26])([CH3:25])[CH3:27])=[O:22])[CH2:31][CH2:30]1

Participants

3

Reactant 2

HCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acidHCID 90204397HCID 90204397, compound

Product 1

HCID 90203565HCID 90203565, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and tert-butyl 2-amino-3-cyclopropyl-2-methyl-propanoate (example 186b) as starting materials and isolated (105 mg, 31%); MS (ESI, m/z): 443.6 (M+H+).

Workup

  1. customisolated (105 mg, 31%)

Sources & evidence

ORD record
ord-325246533a654870a3fdd29d7648372f
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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