1354953-76-6 → HCID 76281193, compound

HRID 1480264Notes

Reaction equation

HRID 1480264 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.Cl.[NH2:20][CH:21]([CH:26]1[CH2:28][CH2:27]1)[CH2:22][C:23]([NH2:25])=[O:24]>>[NH2:25][C:23](=[O:24])[CH2:22][CH:21]([NH:20][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])[CH:26]1[CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 545951511354953-76-6HCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid

Product 1

HCID 76281193HCID 76281193, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (Example 48c) and 3-amino-3-cyclopropylpropanamide hydrochloride (CAN 1354953-76-6) as starting materials and isolated (50 mg, 35%); MS (ESI, m/z): 372.5 (M+H+).

Workup

  1. customisolated (50 mg, 35%)

Sources & evidence

ORD record
ord-fec184b3e47740a5ad65ec4d8df66250
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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