Ammonium Chloride → HCID 90214971, compound

HRID 1480274Notes

Reaction equation

[CH:1]1([C:4]2[C:5]([O:21][C@@H:22]([CH3:27])[C:23]([F:26])([F:25])[F:24])=[CH:6][C:7]([C:10]([NH:12][CH:13]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:14]([OH:16])=O)=[O:11])=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[Cl-].[NH4+:29]>>[NH2:29][C:14](=[O:16])[CH:13]([NH:12][C:10]([C:7]1[CH:6]=[C:5]([O:21][C@@H:22]([CH3:27])[C:23]([F:24])([F:26])[F:25])[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:11])[C:17]([CH3:20])([CH3:19])[CH3:18]

Participants

Reactant 2

HCID 25517Ammonium Chloride

HCID 902035392-[[5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoic acid

Product 1

HCID 90214971HCID 90214971, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 2-[[5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoic acid (Example 199b) and ammonium chloride as starting materials and isolated (105 mg, 88%); MS (ESI, m/z): 388.6 (M+H+).

Workup

customisolated (105 mg, 88%)

Sources & evidence

ORD record: ord-7eec2bc203494b92ab8d09d17c6b0129
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09409866B2

Reaction notes

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