Oxalate → HCID 90204920, compound

HRID 1480279Notes

Reaction equation

[CH:1]1([C:4]2[C:5]([O:21][C@@H:22]([CH3:27])[C:23]([F:26])([F:25])[F:24])=[CH:6][C:7]([C:10]([NH:12][CH:13]([C:17]([CH3:20])([CH3:19])[CH3:18])[C:14]([OH:16])=O)=[O:11])=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH:28]1[C:31]2([CH2:34][O:33][CH2:32]2)[CH2:30][CH2:29]1.C([O-])(=O)C([O-])=O>>[CH:1]1([C:4]2[C:5]([O:21][C@@H:22]([CH3:27])[C:23]([F:24])([F:26])[F:25])=[CH:6][C:7]([C:10]([NH:12][CH:13]([C:17]([CH3:18])([CH3:20])[CH3:19])[C:14]([N:28]3[C:31]4([CH2:34][O:33][CH2:32]4)[CH2:30][CH2:29]3)=[O:16])=[O:11])=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

Reactant 3

HCID 71081Oxalate

HCID 547591466-Oxa-1-azaspiro(3.3)heptane

HCID 902035392-[[5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoic acid

Product 1

HCID 90204920HCID 90204920, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 2-[[5-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-methyl-ethoxy]pyridine-2-carbonyl]amino]-3,3-dimethyl-butanoic acid (Example 199b) and 6-Oxa-1-azaspiro[3.3]heptane, ethanedioate (1:2) (CAN 1380571-72-1) as starting materials and isolated (23 mg, 38%); MS (ESI, m/z): 470.6 (M+H+).

Workup

customisolated (23 mg, 38%)

Sources & evidence

ORD record: ord-980db6929550421e8004a936d05c1674
Source dataset: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09409866B2

Reaction notes

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