5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid → HCID 76280925, compound

HRID 1480304Notes

Reaction equation

HRID 1480304 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[CH3:19][C:20]1[O:24][C:23]([CH:25]([C:27]2([CH3:31])[CH2:30][O:29][CH2:28]2)[NH2:26])=[N:22][N:21]=1>>[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([NH:26][CH:25]([C:23]3[O:24][C:20]([CH3:19])=[N:21][N:22]=3)[C:27]3([CH3:31])[CH2:30][O:29][CH2:28]3)=[O:12])=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acidHCID 90204007HCID 90204007, compound

Product 1

HCID 76280925HCID 76280925, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example 48c) and (5-methyl-1,3,4-oxadiazol-2-yl)-(3-methyloxetan-3-yl)methanamine (example 245b) as starting materials and isolated (25 mg, 35%); MS (ESI, m/z): 427.7 (M+H+).

Workup

  1. customisolated (25 mg, 35%)

Sources & evidence

ORD record
ord-ecf20741f8fd4129bc5df5828bf7acc0
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

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