5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid → HCID 90204763, compound

HRID 1480322Notes

Reaction equation

HRID 1480322 reaction equation
[CH:1]1([C:4]2[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:6][C:7]([C:10]([OH:12])=O)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.[NH2:19][CH:20]([C:23]1([CH3:27])[CH2:26][O:25][CH2:24]1)[C:21]#[N:22]>>[C:21]([CH:20]([C:23]1([CH3:27])[CH2:26][O:25][CH2:24]1)[NH:19][C:10]([C:7]1[CH:6]=[C:5]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[C:4]([CH:1]2[CH2:2][CH2:3]2)=[CH:9][N:8]=1)=[O:12])#[N:22]

Participants

3

Reactant 2

HCID 902036745-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acidHCID 90204553HCID 90204553, compound

Product 1

HCID 90204763HCID 90204763, compound

Procedure

The title compound was synthesized in analogy to Example 112e, using 5-Cyclopropyl-4-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example 48c) and 2-amino-2-(3-methyloxetan-3-yl)acetonitrile (example 251b) as starting materials and isolated (105 mg, 85%); MS (ESI, m/z): 370.3 (M+H+).

Workup

  1. customisolated (105 mg, 85%)

Sources & evidence

ORD record
ord-d9a163fafba24bc0a13d56941b502231
Source dataset
uspto-grants-2016_08
Patent number
US09409866B2

Reaction notes

Loading…